Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects

Br J Clin Pharmacol. 1978 Aug;6(2):129-33. doi: 10.1111/j.1365-2125.1978.tb00837.x.


1. The pharmacological actions of a new short acting loop diuretic were investigated in nine healthy male subjects and compared with those of frusemide and bumetanide. Subjects received 6 mg piretanide/day, 40 mg frusemide/day or 1 mg bumetanide/day for a period of 1 week. 2. Comparison of effects following the first dose administered showed that 6 mg piretanide is of similar potency to 40 mg frusemide in terms of diuresis, natriuresis and kaliuresis but is less potent than 1 mg bumetanide. 3. All three diuretics caused a decrease in urate excretion and a rise in serum uric acid. 4. Piretanide was well tolerated. Further investigation is required to ascertain what clinical advantage it offers over frusemide and bumetanide.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Bumetanide / pharmacology*
  • Diuretics / pharmacology*
  • Electrolytes / urine*
  • Furosemide / pharmacology*
  • Humans
  • Male
  • Potassium / urine
  • Sodium / urine
  • Time Factors
  • Uric Acid / urine*


  • Diuretics
  • Electrolytes
  • Bumetanide
  • Uric Acid
  • Furosemide
  • Sodium
  • Potassium