Factor VII related antigen as an endothelial cell marker in benign and malignant diseases

Virchows Arch A Pathol Anat Histol. 1981;391(2):217-25. doi: 10.1007/BF00437598.


The presence and distribution of Factor VIII related antigen (FVIIR:Ag) in formation fixed, paraffin embedded tissue were studied in benign and malignant vascular tumors, inflammatory vascular diseases, normal tissue from various organs and a number of malignant tumors. The unlabeled peroxidase-anti-peroxidase method was utilized. Immunostaining was observed only in endothelial cells, in tumor cells of endothelial cell origin and in megakaryocytes and platelets. The staining method gave a distinct picture of the vascular pattern in all types of tissue examined. The demonstration of FVIIIR:Ag by means of the immunoperoxidase technique is considered a valuable method in diagnosing tumors of vascular origin. The method also facilitates detection of vascular invasion of malignant tumors in small caliber vessels.

MeSH terms

  • Antigens / analysis*
  • Blood Platelets / immunology
  • Endothelium / immunology
  • Factor VIII / analysis
  • Factor VIII / immunology*
  • Humans
  • Immunoenzyme Techniques
  • Megakaryocytes / immunology
  • Neoplasms / diagnosis
  • Vascular Diseases / diagnosis
  • von Willebrand Factor


  • Antigens
  • von Willebrand Factor
  • Factor VIII