Severe kyphoscoliosis, breathing, and sleep: the "Quasimodo" syndrome during sleep

Chest. 1981 Jun;79(6):626-30. doi: 10.1378/chest.79.6.626.


Five adult subjects with severe kyphoscoliosis were monitored during sleep. Several types of breathing abnormalities, including obstructive apnea and hypopnea, were noted. The lowest oxygen desaturations occurred during rapid eye movement (REM) sleep. Arterial pressure, continuously measured in one subject, progressively increased throughout the night in association with abnormal breathing. The use of a cuirass ventilator did not improve the nocturnal problem.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Apnea / physiopathology
  • Blood Pressure
  • Carbon Dioxide
  • Electrocardiography
  • Humans
  • Kyphosis / physiopathology*
  • Male
  • Middle Aged
  • Monitoring, Physiologic
  • Respiration*
  • Respiratory Function Tests
  • Scoliosis / physiopathology*
  • Sleep Apnea Syndromes / physiopathology*
  • Sleep, REM
  • Syndrome


  • Carbon Dioxide