Neurological complications in hemophilia

Acta Paediatr Scand. 1981 Mar;70(2):235-41. doi: 10.1111/j.1651-2227.1981.tb05548.x.


The clinical data of 59 patients with hemophilia A or B are reviewed. Intracranial bleeding was observed in 6 patients and a minor bleeding episode was assumed in a further 8 patients. Neurosurgical evacuation of the hematoma was necessary in 2 cases and the remaining patients were treated solely with factor VIII or IX. In 10 patients a peripheral nerve lesion was observed, paresis of the femoral nerve being the most frequent (5 cases). Two patients showed a lesion of the lumbar and sacral plexus, 2 patients a lesion of the radial nerve and one patient a lesion of the cutaneous femoris lateralis nerve.

MeSH terms

  • Adolescent
  • Adult
  • Cerebral Hemorrhage / etiology
  • Child
  • Child, Preschool
  • Factor IX / therapeutic use
  • Factor VIII / therapeutic use
  • Female
  • Hematoma, Subdural / etiology
  • Hemophilia A / complications*
  • Hemophilia A / drug therapy
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Muscular Atrophy / etiology
  • Nervous System Diseases / etiology*
  • Wounds and Injuries / complications


  • Factor VIII
  • Factor IX