A study of growth hormone release in man after oral administration of amino acids

Curr Med Res Opin. 1981;7(7):475-81. doi: 10.1185/03007998109114287.


A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that oral administration of a combination of two amino acids (1200 mg 1-lysine plus 1200 mg 1-arginine) provoked a release of pituitary somatotropin and insulin. This phenomenon was reproducible and the growth hormone secreted in response to this stimulation had biological activity (as demonstrated by a radioreceptor assay and somatomedin induction). The effect appeared to be specific to the combination of the two amino acids; neither of the amino acids demonstrated appreciable stimulating activity when administered alone, even at the same doses.

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Arginine / pharmacology*
  • Growth Hormone / blood*
  • Humans
  • Insulin / blood*
  • Lysine / pharmacology*
  • Male
  • Radioimmunoassay
  • Radioligand Assay
  • Time Factors


  • Insulin
  • Growth Hormone
  • Arginine
  • Lysine