Loss of nitroglycerin from solutions to intravenous plastic containers: a theoretical treatment

J Pharm Sci. 1981 Jul;70(7):798-800. doi: 10.1002/jps.2600700723.

Abstract

The physical instability of nitroglycerin solutions in plastic containers has been reported extensively. A systematic study of potency loss in plastic infusion bags were reported recently. This paper presents a theoretical treatment of the data and a proposed model consisting of adsorption onto the surface followed by partitioning into the plastic.

MeSH terms

  • Adsorption
  • Chemistry, Pharmaceutical
  • Drug Packaging
  • Drug Stability
  • Injections, Intravenous
  • Nitroglycerin / analysis*
  • Plastics
  • Solutions

Substances

  • Plastics
  • Solutions
  • Nitroglycerin