Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice

J Exp Zool. 1981 Apr;216(1):113-9. doi: 10.1002/jez.1402160112.


The distribution and kinetic parameters of tyrosinase (EC 1.14.-18.1) from anagen hair follicles of the C57BL/6J mouse and several c-locus mutants were investigated. The results showed that c-locus mutations not only influenced the total tyrosinase activity, but the subcellular distribution as well. The kinetic parameters of tyrosinase were not influenced by the pigment mutations, suggesting that the mutations were not influencing the structure of the enzyme.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Catechol Oxidase / metabolism*
  • Enzyme Activation
  • Hair / enzymology*
  • Hair / ultrastructure
  • Kinetics
  • Melanins / biosynthesis*
  • Mice
  • Mice, Inbred C57BL
  • Monophenol Monooxygenase / metabolism*
  • Mutation


  • Melanins
  • Catechol Oxidase
  • Monophenol Monooxygenase