Volume exclusion errors and the determination of serum zinc

Clin Chim Acta. 1978 Aug 15;88(1):49-56. doi: 10.1016/0009-8981(78)90148-1.


Volume exclusion gives rise to positive errors in the results of plasma or serum zinc determinations by methods in which protein is precipitated and the zinc extracted into solution. The error is amplified if two extraction steps are employed, and may be +20% or more. The same effects must be expected in any analysis involving comparable extraction procedures, whatever the substance being determined.

MeSH terms

  • False Positive Reactions
  • Humans
  • Mathematics
  • Solubility
  • Spectrophotometry, Atomic / methods
  • Zinc / blood*


  • Zinc