Comparison of the orally administered anti-allergy agent, ketotifen with sodium cromoglycate in the prophylaxis of bronchial asthma

Respiration. 1981;41(4):264-9. doi: 10.1159/000194391.


Ketotifen at an oral dose of 1 mg twice daily was compared with sodium cromoglycate a dose of 20 mg four times daily by inhalation in a double-blind parallel group study lasting 12 weeks. Data relating to 60 patients were analyzed and showed that stabilised asthmatics continued to be stable during the 12-week treatment period on both drugs. There was a significant reduction within the ketotifen group in day and night scores at the end of the 12-week period and more patients on ketotifen had increased evening peak expiratory flow rate values compared with sodium cromoglycate. Ketotifen and sodium cromoglycate were equally well tolerated.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Asthma / drug therapy*
  • Clinical Trials as Topic
  • Cromolyn Sodium / administration & dosage
  • Cromolyn Sodium / therapeutic use*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Ketotifen / administration & dosage
  • Ketotifen / therapeutic use*
  • Male
  • Middle Aged


  • Cromolyn Sodium
  • Ketotifen