Cyclic neutropenia. A tale of two brothers and their family

Am J Pediatr Hematol Oncol. Summer 1981;3(2):127-33.


A family history encompassing four generations is presented. Definite cyclic neutropenia has been noted in two generations. In one member, the symptoms abated as she grew older. One 12-year-old member died of clostridial septicemia secondary to gangrene of the terminal ileum. At autopsy he was found to have amyloidosis. A trial of lithium carbonate therapy was carried out in a 7-year-old male but a positive hematologic response was not obtained.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Agranulocytosis / genetics*
  • Amyloidosis / complications
  • Amyloidosis / pathology
  • Child
  • Female
  • Humans
  • Leukocyte Count
  • Lithium / therapeutic use
  • Lithium Carbonate
  • Male
  • Middle Aged
  • Neutropenia / drug therapy
  • Neutropenia / genetics*
  • Neutropenia / pathology
  • Pedigree
  • Periodicity*
  • Syndrome


  • Lithium Carbonate
  • Lithium