Vitamin A and E requirements during total parenteral nutrition

JPEN J Parenter Enteral Nutr. 1981 Sep-Oct;5(5):420-3. doi: 10.1177/0148607181005005420.


Studies were undertaken to determine rational dosages of vitamin A and E during long-term total parenteral nutrition (TPN). Four kinds of vitamin prescriptions containing different amounts of vitamin A and E were prepared from commercially available products and/or hospital pharmacy products. Patients were divided into four groups according to the vitamin prescription used. Plasma vitamin levels of different patient groups were determined by a modified fluorimetric method and were compared with those of a normal subject group. The stability of vitamin A and E in TPN solution after admixing was determining by measuring the remaining vitamin contents by high pressure liquid chromatography. From the results, it was concluded that 1) about 50% of vitamin A was decomposed by sunlight (about 2000 lux) 3 hr after admixing and an orange-colored vinyl cover could protect its photodecomposition; 2) vitamin E was stable at any condition tested; 3) 2500 IU of vitamin A and 15 IU of vitamin E could meet the daily requirements; 4) the plasma levels of vitamin A and E were correlative (p less than 0.01); and 5) concomitant administration of vitamin E was essential to keep the poorer level of vitamin A in plasma.

MeSH terms

  • Drug Stability
  • Humans
  • Nutritional Requirements
  • Parenteral Nutrition*
  • Parenteral Nutrition, Total*
  • Vitamin A / administration & dosage
  • Vitamin A / blood
  • Vitamin A / metabolism*
  • Vitamin E / administration & dosage
  • Vitamin E / blood
  • Vitamin E / metabolism*


  • Vitamin A
  • Vitamin E