Carcinogenicity bioassays of vinyl chloride monomer: a model of risk assessment on an experimental basis

Environ Health Perspect. 1981 Oct;41:3-29. doi: 10.1289/ehp.81413.

Abstract

Data are presented regarding the final results of the Bentivoglio (Bologna) project on long-term carcinogenicity bioassays of vinyl chloride (VC). The experimental project studied the effects of the monomer, administered by different routes, concentrations and schedules of treatment, to animals (near 7000) of different species, strains, sex and age. To our knowledge this is the largest experimental carcinogenicity study performed on a single compound by a single institution. The results indicate that VC is a multipotential carcinogen, affecting a variety of organs and tissues. In the experimental conditions studied, the neoplastic effects of the monomer were also detected at low doses. The experimental and biological factors greatly affect the neoplastic response to VC. Long-term carcinogenicity bioassays are, at present, a unique tool for the identification and quantification of environmental and occupational risks. Precise and highly standardized experimental procedures are needed to obtain data for risk assessment.

MeSH terms

  • Aerosols
  • Animals
  • Carcinogens*
  • Costs and Cost Analysis
  • Cricetinae
  • Dose-Response Relationship, Drug
  • Enteral Nutrition
  • Female
  • Injections, Intraperitoneal
  • Injections, Subcutaneous
  • Italy
  • Male
  • Mesocricetus
  • Mice
  • Neoplasms, Experimental / pathology
  • Rats
  • Rats, Inbred Strains
  • Vinyl Chloride / administration & dosage
  • Vinyl Chloride / toxicity*
  • Vinyl Compounds / toxicity*

Substances

  • Aerosols
  • Carcinogens
  • Vinyl Compounds
  • Vinyl Chloride