Development of insulin-dependent diabetes mellitus during the hemolytic-uremic syndrome

J Pediatr. 1982 Apr;100(4):541-5. doi: 10.1016/s0022-3476(82)80749-x.

Abstract

Three children developed hyperglycemia and ketoacidosis three, eight, and 60 days after the onset of hemolytic-uremic syndrome. During hyperglycemia, the two patients studied had dramatically low insulin concentrations. Circulating islet-cell and insulin antibodies were not detected. These studies suggest that pancreatic beta cell dysfunction may occur during hemolytic-uremic syndrome, and that the serum glucose concentration should be closely monitored during this disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / metabolism
  • Child
  • Child, Preschool
  • Diabetes Mellitus / etiology*
  • Diabetic Ketoacidosis / etiology
  • Diazoxide / therapeutic use
  • Female
  • Hemolytic-Uremic Syndrome / blood
  • Hemolytic-Uremic Syndrome / complications*
  • Hemolytic-Uremic Syndrome / therapy
  • Humans
  • Hyperglycemia / etiology
  • Insulin / blood
  • Islets of Langerhans / physiopathology
  • Peritoneal Dialysis

Substances

  • Blood Glucose
  • Insulin
  • Diazoxide