Reference values for 51Cr-EDTA clearance as a measure of glomerular filtration rate

Scand J Clin Lab Invest. 1981 Oct;41(6):611-6. doi: 10.3109/00365518109090505.


Reference values for glomerular filtration rate (GFR) were defined using eight reports including epidemiological studies and studies in kidney donors. Studies using both inulin and 51Cr-EDTA were included. GFR decreased with age, by 4 ml/min decade below the age of 50, and 10 ml/min decade above 50 years of age. No sex difference was found. +/- 2 SD was equal to 25 ml/min at all ages. Based on these findings a nomogram for GFR is presented. Emphasis is given to the use of plasma clearance of 51Cr-EDTA estimated with single injection technique as the new reference method for GFR measurement.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Chromium Radioisotopes*
  • Edetic Acid*
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Male
  • Middle Aged
  • Reference Values
  • Sex Factors


  • Chromium Radioisotopes
  • Edetic Acid