Pharmacology of hallucinations induced by long-term drug therapy

Am J Psychiatry. 1982 Apr;139(4):494-7. doi: 10.1176/ajp.139.4.494.


The authors studied 20 patients with Parkinson's disease and prominent hallucinations related to dopaminergic or anticholinergic therapy. The character of the hallucinations appeared distinct from the classic description of either acute anticholinergic or acute aminergic hallucinatory states. Manipulation of either kind of drug could precipitate or relieve hallucinations in a given patient, which suggests that the dopaminergic/cholinergic systems are reciprocally active in the pathophysiology of long-term drug-induced hallucinatory states in this population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiparkinson Agents / adverse effects*
  • Dopamine / metabolism
  • Dose-Response Relationship, Drug
  • Hallucinations / chemically induced*
  • Hallucinations / metabolism
  • Humans
  • Long-Term Care
  • Parasympatholytics / adverse effects
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / metabolism
  • Serotonin / metabolism


  • Antiparkinson Agents
  • Parasympatholytics
  • Serotonin
  • Dopamine