Renal hypomagnesaemia in human diabetes mellitus: its relation to glucose homeostasis

Eur J Clin Invest. 1982 Feb;12(1):81-5. doi: 10.1111/j.1365-2362.1982.tb00942.x.


Interrelations between magnesium and glucose metabolism were studied in 215 insulin-treated diabetic out-patients aged 7-70 years. All had normal serum creatinine concentrations (below 115 mumol/l) and none had other diseases or received drugs known to interfere with mineral metabolism. A definite hypomagnesaemia (less than normal mean - 2 SD) and hypermagnesiuria (greater than normal mean + 2 SD) occurred in 38.6% and 55% of the patients. In the presence of hypermagnesiuria the serum magnesium concentration was inversely correlated to the urinary magnesium excretion rate (R = -0.23, P less than 0.02). Serum magnesium correlated inversely with both fasting blood glucose (R = -0.32, P less than 0.001) and the urinary glucose excretion rate (R = -0.22, P less than 0.005). The urinary magnesium excretion rate correlated directly with the same variables (R = 0.27, P less than 0.001 and R = 0.58, P less than 0.001, respectively). These data indicate that the net tubular reabsorption of magnesium is decreased in diabetic patients in presence of hyperglycaemia, leading to hypermagnesiuria and hypomagnesaemia.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Diabetes Mellitus / metabolism*
  • Diabetes Mellitus / physiopathology
  • Female
  • Glucose / metabolism*
  • Homeostasis
  • Humans
  • Kidney / physiopathology*
  • Magnesium / metabolism*
  • Magnesium Deficiency / etiology
  • Male
  • Middle Aged


  • Magnesium
  • Glucose