Review
Mutational events in mouse myeloma cells
- PMID: 6807601
Item in Clipboard
Review
Mutational events in mouse myeloma cells
Crit Rev Immunol.
1981 Sep.
Abstract
Cultured mouse myeloma cells frequently generate variants in immunoglobulin expression and structure. In this paper the authors will review the phenotypes of the variants which have been identified and discuss the mechanisms which may be responsible for the somatic instability of the immunoglobulin genes in mouse myeloma cells.
Similar articles
-
Analysis of immunoglobulin mRNA in murine myeloma cell variants defective in the synthesis of the light or heavy polypeptide chains.J Immunol. 1982 Feb;128(2):684-90. J Immunol. 1982. PMID: 6798120 No abstract available.
-
Molecular characterization of a nonsecreting myeloma mutant.Eur J Immunol. 1983 Apr;13(4):301-5. doi: 10.1002/eji.1830130406. Eur J Immunol. 1983. PMID: 6406235
-
Synthesis of immunoglobulin by substrate attached mouse myeloma cells.J Cell Physiol. 1976 Jun;88(2):247-51. doi: 10.1002/jcp.1040880214. J Cell Physiol. 1976. PMID: 818094
-
Expression of immunoglobulin genes.Essays Biochem. 1982;18:1-39. Essays Biochem. 1982. PMID: 6821290 Review. No abstract available.
-
The identification of mouse myeloma cells which have undergone mutations in immunoglobulin production.Soc Gen Physiol Ser. 1974;29:233-44. Soc Gen Physiol Ser. 1974. PMID: 4215140 Review. No abstract available.
Cited by
-
Ectopic recombination within homologous immunoglobulin mu gene constant regions in a mouse hybridoma cell line.Mol Cell Biol. 1992 Oct;12(10):4422-32. doi: 10.1128/mcb.12.10.4422-4432.1992. Mol Cell Biol. 1992. PMID: 1406631 Free PMC article.
-
Mutant monoclonal antibodies with alterations in biological functions.J Exp Med. 1982 Oct 1;156(4):1131-48. doi: 10.1084/jem.156.4.1131. J Exp Med. 1982. PMID: 6818317 Free PMC article.
-
Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen.J Exp Med. 1992 Sep 1;176(3):855-66. doi: 10.1084/jem.176.3.855. J Exp Med. 1992. PMID: 1512548 Free PMC article.
-
Engineering soluble major histocompatibility molecules: why and how.Immunol Res. 1987;6(1-2):101-16. doi: 10.1007/BF02918107. Immunol Res. 1987. PMID: 3114395 Review. No abstract available.
-
Mutations that influence the secretory path in animal cells.Biochem J. 1983 Oct 15;216(1):1-9. doi: 10.1042/bj2160001. Biochem J. 1983. PMID: 6360156 Free PMC article. Review. No abstract available.