Effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on the cellular levels of epoxide hydratase, cytochrome P-450b, and NADPH-cytochrome c (P-450) oxidoreductase messenger ribonucleic acids

J Biol Chem. 1982 Sep 25;257(18):11032-6.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Acetylaminofluorene / analogs & derivatives*
  • 2-Acetylaminofluorene / pharmacology*
  • Animals
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P-450 Enzyme System / metabolism
  • Epoxide Hydrolases / genetics*
  • Epoxide Hydrolases / metabolism
  • Hydroxyacetylaminofluorene / pharmacology*
  • Kinetics
  • Liver / drug effects
  • Liver / enzymology*
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • NADPH-Ferrihemoprotein Reductase / genetics*
  • NADPH-Ferrihemoprotein Reductase / metabolism
  • RNA, Messenger / genetics*
  • Rats
  • Rats, Inbred Strains
  • Transcription, Genetic / drug effects*

Substances

  • RNA, Messenger
  • Hydroxyacetylaminofluorene
  • Cytochrome P-450 Enzyme System
  • 2-Acetylaminofluorene
  • NADPH-Ferrihemoprotein Reductase
  • Epoxide Hydrolases