75Se-methionine labelled Trypanosoma cruzi blood trypomastigotes: opsonization by chronic infection serum facilitates killing in spleen and liver

Abstract

Blood trypomastigote forms of Trypanosoma cruzi have been labelled with 75Se-methionine. Opsonization by sera from mice chronically infected with T. cruzi promoted their uptake by both liver and spleen. Opsonized parasites within spleens and livers were less infectious when transferred to normal recipients demonstrating in situ parasite killing by these organs.