Adherence to human monocytes of red cells from autoimmune haemolytic anaemia and red cells sensitized with alloantibodies

Haematologia (Budap). 1982;15(1):135-45.

Abstract

Red cells sensitized with autoantibodies are able to adhere in vitro to autologous monocytes and monocytes from healthy individuals. A direct relationship between the degree of sensitization and the percentage of rosettes was not observed, while such a correlation was found if red cells sensitized with anti-Rh alloantibodies were used. Sometimes the adherence of red cell from AIHA was observed although the sensitization was weaker than that of the control erythrocytes sensitized with anti-CD serum which did adhere to monocytes. In patients with AIHA some relation was found between the adherence assay, haemolysis in vivo and treatment with prednisone.

MeSH terms

  • Anemia, Hemolytic, Autoimmune / blood
  • Anemia, Hemolytic, Autoimmune / immunology*
  • Autoantibodies
  • Erythrocytes / immunology
  • Erythrocytes / metabolism*
  • Humans
  • Immunoglobulin G / classification
  • Isoantibodies
  • Monocytes / metabolism*
  • Rh-Hr Blood-Group System / immunology
  • Rosette Formation*

Substances

  • Autoantibodies
  • Immunoglobulin G
  • Isoantibodies
  • Rh-Hr Blood-Group System