Increased polyunsaturated fatty acids in developing and regenerating peripheral nerve

Biochim Biophys Acta. 1982 Sep 14;712(3):542-6. doi: 10.1016/0005-2760(82)90282-x.

Abstract

Characteristic fatty acids of peripheral nerve myelin are mainly saturated and monounsaturated. A marked increase of polyunsaturated fatty acids, particularly arachidonic acid, was found in endoneurial phosphatidylethanolamine of both developing and regenerating rat sciatic nerve, suggesting a close association between polyunsaturated fatty acids and peripheral nerve myelination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Arachidonic Acid
  • Arachidonic Acids / metabolism
  • Fatty Acids, Unsaturated / metabolism*
  • Kinetics
  • Male
  • Nerve Regeneration*
  • Oleic Acid
  • Oleic Acids / metabolism
  • Phosphatidylethanolamines / metabolism
  • Rats
  • Rats, Inbred Strains
  • Sciatic Nerve / growth & development*
  • Sciatic Nerve / physiology
  • Structure-Activity Relationship

Substances

  • Arachidonic Acids
  • Fatty Acids, Unsaturated
  • Oleic Acids
  • Phosphatidylethanolamines
  • Arachidonic Acid
  • Oleic Acid