Abstract
An anti-I-Ek alloantiserum was shown to react with purified human Ia preparation. All Ia preparations tested were actively bound irrespective of their HLA-DR phenotypes. However, from a quantitative point of view, DR7 molecules were significantly less reactive. No reaction was observed with isolated Ia subunits. Only molecules carrying DR determinants, but not those carrying either DC1 or BR4X7 determinants, were bound.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antilymphocyte Serum / pharmacology
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Binding Sites, Antibody
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Genes, MHC Class II*
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HLA-DR Antigens
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Histocompatibility Antigens / genetics*
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Histocompatibility Antigens Class II / immunology
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Humans
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Mice
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Mice, Inbred A
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Rabbits
Substances
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Antilymphocyte Serum
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HLA-DR Antigens
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Histocompatibility Antigens
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Histocompatibility Antigens Class II
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I-E-antigen