Gilvocarcins, new antitumor antibiotics. 4. Mode of action

J Antibiot (Tokyo). 1982 Aug;35(8):1038-41. doi: 10.7164/antibiotics.35.1038.

Abstract

The mode of action of gilvocarcins was studied. Gilvocarcins V, M and A possessed antibacterial activities decreasing in that order. Gilvocarcin V inhibited DNA synthesis in Bacillus subtilis through strong interaction with DNA and resulting cleavage. Gilvocarcin M showed interaction with DNA and a small change in DNA mobility upon electrophoresis in agarose gel, while gilvocarcin A showed no interaction with DNA, thus reflecting their relative biological activities.

MeSH terms

  • Aminoglycosides*
  • Anti-Bacterial Agents*
  • Antibiotics, Antineoplastic / pharmacology*
  • Bacillus subtilis / metabolism
  • Bacteria / drug effects
  • Bacterial Proteins / biosynthesis
  • Coumarins
  • DNA, Bacterial / metabolism
  • Glycosides / pharmacology
  • Nucleic Acids / biosynthesis

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Bacterial Proteins
  • Coumarins
  • DNA, Bacterial
  • Glycosides
  • Nucleic Acids
  • gilvocarcin M
  • gilvocarcin V