Effect of cycloheximide on different stages of Drosophila melanogaster

Toxicol Lett. 1982 Sep;13(1-2):105-12. doi: 10.1016/0378-4274(82)90145-x.


Cycloheximide, an antibiotic inhibiting protein synthesis, exerted a toxic effect on different developmental stages egg, larva and adult of Drosophila melanogaster. At the egg stage the early embryos were most sensitive. With larvae, a strong decrease in viability was found, with no sex difference. In adults, there was a dose-effect relationship, mortality increasing with concentration. At 10 and 15 mM, males were more sensitive than females. There were consistent differences between the control and cycloheximide-fed females in respect of the average number of eggs deposited and offspring produced.

MeSH terms

  • Animals
  • Cycloheximide / toxicity*
  • Diffusion
  • Drosophila melanogaster / drug effects*
  • Eggs
  • Larva
  • Reproduction / drug effects
  • Time Factors


  • Cycloheximide