Induced basal normoglycemia and altered platelet aggregation in non-insulin-dependent diabetes

Diabetes Care. 1982 Jul-Aug;5(4):433-7. doi: 10.2337/diacare.5.4.433.


Non-insulin-dependent diabetic subjects had abnormally raised in vitro platelet aggregation rates to collagen or ristocetin when thought to be "well-controlled" on diet alone but shown to have raised basal plasma glucose levels. Basal normoglycemia, induced with either ultralente insulin or chlorpropamide, was associated with a significant reduction of the enhanced platelet aggregation rates to normal. Some sulfonylurea drugs have been reported to have specific anti-platelet aggregatory properties, but the degree of plasma glucose control is probably more relevant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / analysis*
  • Diabetes Mellitus / blood*
  • Factor VIII / analysis
  • Humans
  • Platelet Aggregation*


  • Blood Glucose
  • Factor VIII