Infections with non-penicillinase-producing Neisseria gonorrhoeae treated with cefuroxime: treatment failures

Sex Transm Dis. Oct-Dec 1982;9(4):200-1. doi: 10.1097/00007435-198210000-00007.

Abstract

Two men who acquired acute gonococcal urethritis in The Netherlands and who were treated with cefuroxime (1.5 g given intramuscularly) failed to respond to this therapy. Pre- and post-treatment isolates of Neisseria gonorrhoeae from these patients had MICs of 0.5 and 1.0 microgram of cefuroxime/ml.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cefuroxime / therapeutic use*
  • Cephalosporins / therapeutic use*
  • Drug Resistance, Microbial
  • Gonorrhea / drug therapy*
  • Gonorrhea / microbiology
  • Humans
  • Male
  • Neisseria gonorrhoeae / drug effects
  • Neisseria gonorrhoeae / enzymology
  • Penicillinase / biosynthesis
  • Urethritis / drug therapy*
  • Urethritis / microbiology

Substances

  • Cephalosporins
  • Penicillinase
  • Cefuroxime