Appearance of strong transplantation antigens in non-immunogenic lymphoma following drug-treatment in vivo

J Immunopharmacol. 1980;2(2):189-212. doi: 10.3109/08923978009026397.

Abstract

A chemically induced lymphosarcoma line (LSBM-1) of C57BL/10 (H-2b) origin lacks detectable TATA and is scarcely immunogenic for H-2-incompatible congenic recipients. New antigenic specificities, defined as drug-mediated tumor antigen(s) (DMTA) were found in a subline (LBD-1) obtained by in vivo treatment of LSBM-1 with the anti-neoplastic agent dimethyl-1-triazeno-imidazole-carboxamide (DTIC) over several transplant generations. It was concluded that the presence of detectable TATA is not a prerequisite for the induction of new antigenic specificities (DMTA).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology*
  • Dacarbazine
  • Female
  • Histocompatibility Antigens / immunology*
  • Lymphoma / chemically induced
  • Lymphoma / immunology*
  • Male
  • Mice
  • Mice, Inbred AKR
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Transplantation Immunology
  • Tumor Cells, Cultured / immunology*

Substances

  • Antigens, Neoplasm
  • Histocompatibility Antigens
  • tumor-associated transplantation antigen
  • Dacarbazine