Killing of blood-stage murine malaria parasites by hydrogen peroxide

Infect Immun. 1983 Jan;39(1):456-9. doi: 10.1128/IAI.39.1.456-459.1983.

Abstract

Both nonlethal Plasmodium yoelii and lethal Plasmodium berghei were killed in vitro by hydrogen peroxide at concentrations as low as 10(-5) M. Higher concentrations were required in the presence of added normal erythrocytes. Injection of hydrogen peroxide in vivo significantly reduced P. yoelii parasitemia but had less effect on P. berghei.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood / parasitology
  • Dose-Response Relationship, Drug
  • Erythrocytes / drug effects
  • Hydrogen Peroxide / metabolism
  • Hydrogen Peroxide / pharmacology*
  • Macrophages / metabolism
  • Mice
  • Plasmodium / drug effects*

Substances

  • Hydrogen Peroxide