Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

Science. 1983 Feb 25;219(4587):983-5. doi: 10.1126/science.6823562.


Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ascites / physiopathology
  • Ascitic Fluid / physiology
  • Capillary Permeability*
  • Cricetinae
  • Guinea Pigs
  • Mice
  • Neoplasms, Experimental / physiopathology*