Trends in serum uric acid levels 1961--1980

Arthritis Rheum. 1983 Jan;26(1):87-93. doi: 10.1002/art.1780260115.


Uric acid levels of adult male volunteers in a longitudinal study of human aging rose steadily between 1961 and 1978. In the 1,141 men with 3 serial physical examinations, who developed no diseases and who took no drugs known to affect uric acid levels, levels rose from means below 5.5 mg/dl in 1961--1963 to means above 6.5 mg/dl in 1975--1978. The best predictor of a longitudinal increase in uric acid level was a gain in weight, but this, and other significant predictors, explained only a small portion of the increase in this population. Preliminary data available from a fourth examination indicate that the rising trend has leveled off.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aging*
  • Alcohol Drinking
  • Body Weight
  • Diet
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Time Factors
  • United States
  • Uric Acid / blood*


  • Uric Acid