The isolation and amino acid composition of senile plaque core protein

Brain Res. 1983 Jan 24;259(2):348-52. doi: 10.1016/0006-8993(83)91273-8.

Abstract

A new method has been developed for the isolation of intact senile (neuritic) plaque cores from post-mortem brains of patients with Alzheimer's disease. The plaque cores were found to be insoluble in various protein denaturants. The amino acid composition of the plaque core protein does not resemble that of any known form of amyloid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / metabolism*
  • Amino Acids / metabolism
  • Amyloid / metabolism*
  • Cerebral Cortex / metabolism
  • Dementia / metabolism*
  • Humans
  • Middle Aged
  • Nerve Tissue Proteins / metabolism*
  • Neurofibrils / metabolism*
  • Neurons / metabolism

Substances

  • Amino Acids
  • Amyloid
  • Nerve Tissue Proteins