Antagonism of vascular serotonin receptors by m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine

Life Sci. 1983 Feb 14;32(7):711-8. doi: 10.1016/0024-3205(83)90303-x.


m-Chlorophenylpiperazine and m-trifluoromethylphenylpiperazine, two compounds that act as agonists at central serotonin receptors mediating certain neuroendocrine, behavioral and serotonin turnover effects, lacked appreciable agonist activity at serotonin receptors mediating contraction of the rat jugular vein. Instead, these compounds were potent antagonists of serotonin-induced contraction of the jugular vein. Apparently these non-indole compounds affect serotonin receptors in various tissues differently, being agonists in brain but mainly antagonists at some peripheral serotonin receptor sites.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Depression, Chemical
  • Jugular Veins
  • Male
  • Muscle Contraction / drug effects
  • Muscle, Smooth, Vascular / drug effects*
  • Piperazines / pharmacology*
  • Quipazine / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Serotonin / drug effects*
  • Serotonin
  • Serotonin Antagonists


  • Piperazines
  • Receptors, Serotonin
  • Serotonin Antagonists
  • 1-(3-trifluoromethylphenyl)piperazine
  • Serotonin
  • Quipazine
  • 1-(3-chlorophenyl)piperazine