The effect of 6-OHDA lesions of the nucleus accumbens septum on schedule-induced drinking, wheelrunning and corticosterone levels in the rat

Pharmacol Biochem Behav. 1983 Jan;18(1):129-36. doi: 10.1016/0091-3057(83)90262-9.


In a series of four experiments the relationship between 6-OHDA lesions of the nucleus accumbens septum (NAS), schedule-induced behaviors and plasma corticosterone levels was explored. Data from the first experiment show a significant decrease in water intake during a scheduled food delivery test hour for 6-OHDA lesioned groups of rats compared with sham or non-lesioned groups of rats, while during the remaining 23 hours of the day water intake was the same for 6-OHDA lesioned and sham lesioned groups. In a second experiment similar decreases in schedule-induced wheelrunning were observed for 6-OHDA lesioned rats when compared with sham lesioned rats. Data from a third experiment showed significant increases in plasma corticosterone levels of rats in the presence of a scheduled food delivery compared with rats given non-scheduled food. In a fourth experiment it was shown that 6-OHDA lesions of the NAS abolish this increase of corticosterone levels in rats on a food delivery schedule. These data extend the findings of Robbins and Koob [19] and show a more general involvement of the dopaminergic pathways of the NAS in schedule-induced behaviors and in concomitant plasma corticosterone changes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Corticosterone / blood*
  • Drinking Behavior / drug effects*
  • Hydroxydopamines / pharmacology*
  • Male
  • Motor Activity / drug effects*
  • Nucleus Accumbens / drug effects
  • Nucleus Accumbens / physiology*
  • Rats
  • Septal Nuclei / physiology*
  • Time Factors


  • Hydroxydopamines
  • 5-hydroxydopamine
  • Corticosterone