Inheritance of immunoglobulin E: genetic model fitting

Am J Med Genet. 1983 Jan;14(1):61-6. doi: 10.1002/ajmg.1320140110.


Total serum immunoglobulin E (IgE) concentration was measured on 316 members of five pedigrees selected through breast cancer probands. Sex- and age-adjusted natural logarithm-transformed IgE level was not found to differ between individuals with breast cancer or with cancer of any site and other relatives. Likelihoods of the polygenic and of one-locus, two-allele major gene and mixed models were computed. The analysis provided evidence for the presence of a polygenic component in the determination of IgE; it did not show evidence of a major gene effect.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Breast Neoplasms / genetics
  • Breast Neoplasms / immunology
  • Female
  • Genes, Dominant
  • Genes, Recessive
  • Humans
  • Immunoglobulin E / genetics*
  • Male
  • Models, Genetic*
  • Pedigree
  • Probability


  • Immunoglobulin E