Healing of experimental corneal wounds treated with topically applied retinoids

Am J Ophthalmol. 1983 Mar;95(3):353-8. doi: 10.1016/s0002-9394(14)78305-9.


We treated experimental corneal epithelial wounds in rabbits with topical retinoids. Treatment with 0.1% all-trans-retinoic acid three times per day resulted in a 21% increase in the healing rate compared to the control eyes. Treatment five times a day resulted in a 35% increase in healing rate. Treatment with topical retinoic acid also promoted corneal deturgescence. Retinyl palmitate, retinyl acetate, retinol, and 13-cis-retinoic acid had no effect on corneal wound healing. These data suggested that topically applied all-trans-retinoic acid may be effective in promoting corneal healing after surgery and in the treatment of persistent and recurring corneal epithelial defects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Animals
  • Cornea / surgery
  • Corneal Injuries*
  • Diterpenes
  • Rabbits
  • Retinyl Esters
  • Tretinoin / administration & dosage*
  • Vitamin A / administration & dosage*
  • Vitamin A / analogs & derivatives
  • Wound Healing / drug effects*


  • Diterpenes
  • Retinyl Esters
  • Vitamin A
  • retinol palmitate
  • retinol acetate
  • Tretinoin