Effects of lesions in the paraventricular nucleus of the hypothalamus on vasopressin and oxytocin contents in brainstem and spinal cord of rat

Brain Res. 1983 Feb 7;260(2):326-9. doi: 10.1016/0006-8993(83)90690-x.


The effects of lesions of the paraventricular nucleus in rat hypothalamus (PVN) on the vasopressin (AVP) and oxytocin (OT) contents of the brainstem and spinal cord, as measured by radioimmunoassay, were studied. AVP decreased by 50% and 80% in brainstem and spinal cord of lesioned animals, whereas OT disappeared almost completely. Therefore, in contrast to OT, the PVN is not the only site of origin of AVP-containing nerve fibers projecting to the brainstem.

MeSH terms

  • Animals
  • Arginine Vasopressin / metabolism*
  • Brain Stem / physiology*
  • Chromatography, High Pressure Liquid
  • Male
  • Oxytocin / metabolism*
  • Paraventricular Hypothalamic Nucleus / physiology*
  • Radioimmunoassay
  • Rats
  • Rats, Inbred Strains
  • Spinal Cord / physiology*


  • Arginine Vasopressin
  • Oxytocin