Tetrodotoxin inhibits the formation of refined retinotopography in goldfish

Brain Res. 1983 Feb;282(3):293-8. doi: 10.1016/0165-3806(83)90068-8.


One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate. During regeneration impulse activity was eliminated by periodic intraocular injections of tetrodotoxin (TTX). At 32-104 days, the retinotopography of the retinotectal projection was measured autoradiographically by intraocular [3H]proline injections simultaneous with either small (10-20 degrees sector) or half retinal mapping lesions. TTX had no effect on the time-course and quality of the regeneration of gross topography seen with half retina mapping, but indefinitely inhibited higher order (refined) retinotopography normally seen by 2 months with retina sector mapping.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials
  • Animals
  • Brain Mapping
  • Goldfish / physiology
  • Nerve Regeneration / drug effects*
  • Optic Nerve / drug effects
  • Optic Nerve / physiology*
  • Optic Nerve Injuries
  • Retina / physiology*
  • Tetrodotoxin / pharmacology*
  • Visual Fields


  • Tetrodotoxin