Monoamine oxidase inhibitors in obsessive-compulsive disorder

J Clin Psychiatry. 1983 Apr;44(4):131-2.


The authors describe the use of monoamine oxidase inhibitors (MAOIs) in eight patients with severe obsessive-compulsive disorder. In four cases, the MAOIs produced rapid and sustained remission of symptoms; no response was seen in four other patients. All patients who responded to MAOIs, but none of the nonresponders, had phobic anxiety and/or panic attacks. Thus, a trial of MAOIs is indicated in obsessive-compulsive disorder, especially when phobic anxiety or panic attacks form part of the clinical picture.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anxiety Disorders / drug therapy
  • Anxiety Disorders / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / drug therapy*
  • Obsessive-Compulsive Disorder / psychology
  • Panic / drug effects
  • Phenelzine / therapeutic use*
  • Phobic Disorders / drug therapy
  • Phobic Disorders / psychology
  • Tranylcypromine / therapeutic use*


  • Tranylcypromine
  • Phenelzine