Glucocorticoid receptors in childhood acute non-lymphocytic leukemia

Leuk Res. 1983;7(1):11-6. doi: 10.1016/0145-2126(83)90053-x.

Abstract

Using a whole-cell assay, we found glucocorticoid receptors (GR) in all 43 consecutive assessable children with newly diagnosed acute non-lymphocytic leukemia (ANLL). The receptor levels ranged from 2146 to 81,308 sites/cell (median = 18,105); these results were similar to those for acute lymphocytic leukemia. Receptor levels were not related to any of these clinical or biological features at diagnosis: age, sex, race, initial leukocyte count, liver or spleen size, presence of CNS disease or Auer rods, [3H] thymidine ( [3H]TdR) labelling index, French-American-British morphology or terminal deoxynucleotidyl transferase activity. Receptor levels also were not related to the initial treatment response or remission duration after therapy that did not include a glucocorticoid. We conclude that GR level has no clinical utility as a marker protein in childhood ANLL.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adolescent
  • Child
  • Child, Preschool
  • DNA Nucleotidylexotransferase / analysis
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Infant
  • Leukemia / drug therapy
  • Leukemia / metabolism*
  • Leukocyte Count
  • Male
  • Neoplasm Metastasis
  • Prognosis
  • Receptors, Glucocorticoid / analysis*
  • Receptors, Steroid / analysis*

Substances

  • Glucocorticoids
  • Receptors, Glucocorticoid
  • Receptors, Steroid
  • DNA Nucleotidylexotransferase