Phencyclidine and behavior: II. Active avoidance learning and radial arm maze performance

Pharmacol Biochem Behav. 1983 Mar;18(3):351-6. doi: 10.1016/0091-3057(83)90453-7.

Abstract

Rats with injections of 4 or 8 mg/kg of phencyclidine (PCP) are impaired in the acquisition of active avoidance learning and radial arm maze performance. This impairment was not due to a change in detectability of aversive stimuli or the inability to perform the correct response. The primary deficit appears to be the inability of PCP injected animals to encode the appropriate attributes (e.g., environmental context, response selection, and emotion) associated with each task.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects*
  • Discrimination Learning / drug effects*
  • Dose-Response Relationship, Drug
  • Male
  • Muridae
  • Orientation / drug effects
  • Phencyclidine / pharmacology*
  • Retention, Psychology / drug effects

Substances

  • Phencyclidine