Effect of thiols on toxicity and carcinostatic activity of cyclophosphamide

Semin Oncol. 1983 Mar;10(1 Suppl 1):35-45.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylcysteine / pharmacology
  • Acrolein / pharmacology
  • Animals
  • Cyclophosphamide / metabolism
  • Cyclophosphamide / toxicity*
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Interactions
  • Liver / enzymology
  • Liver / metabolism*
  • Male
  • Microsomes, Liver / metabolism
  • Mixed Function Oxygenases / metabolism
  • Phosphoramide Mustards / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Sulfhydryl Compounds / pharmacology*
  • Urinary Bladder / drug effects
  • Urinary Bladder / pathology

Substances

  • Phosphoramide Mustards
  • Sulfhydryl Compounds
  • Acrolein
  • Cyclophosphamide
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Acetylcysteine