Early effects of oxygen administration and prognosis in chronic obstructive pulmonary disease and cor pulmonale

Am Rev Respir Dis. 1983 Apr;127(4):399-404. doi: 10.1164/arrd.1983.127.4.399.


The purpose of this study was to develop criteria for predicting survival and clinical improvement with long-term domiciliary home oxygen therapy (LTDO2) in patients with both chronic obstructive pulmonary disease (COPD) and cor pulmonale (CP). Twenty-eight such patients were divided into 2 groups, responders (R) and nonresponders (NR), on the basis of the fall in their mean pulmonary artery pressure (delta PAP) while breathing 28% O2 for 24 h. The R(n = 17) and NR (n = 11) had delta PAP greater than and lesser than 5 mmHg, respectively. Eighty-eight percent of the R, but only 22% of the NR, were alive at the end of 2 yr of LTDO2. Eighty-five percent of R, but only 11% of NR, achieved an end-exercise maximal oxygen consumption (max VO2) greater than 6.5 ml min-1 kg-1. Left ventricular ejection fraction improved while breathing O2 for 48 h in the R only. The NR and R were similar in all other respects. We conclude that delta PAP greater than 5 mmHg and/or max VO2 6.5 ml min-1 kg-1 or greater predict 2-yr survival with LTDO2 in patients with COPD and CP, and it can be useful in planning their management.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Home Nursing
  • Humans
  • Hypertension, Pulmonary / therapy
  • Lung Diseases, Obstructive / therapy*
  • Oxygen Inhalation Therapy*
  • Partial Pressure
  • Prognosis
  • Pulmonary Artery / physiopathology
  • Pulmonary Heart Disease / therapy*
  • Stroke Volume
  • Time Factors