Mitochondrial membrane modifications induced by adriamycin-mediated electron transport

Biochem Pharmacol. 1983 Mar 1;32(5):889-93. doi: 10.1016/0006-2952(83)90593-2.

Abstract

Adriamycin (ADM) was found to have a two-step mode of action on the cardiac mitochondrial membrane. (1) An interaction with cardiolipin (CL) resulted in the formation of an ADM-CL complex able to transfer electrons from NADH to cytochrome c (cyt.c) as well as coenzyme Q (CoQ). This complex formation stimulates an increased activity of NADH-CoQ oxidoreductase (complex I) and CoQ-cyt.c oxidoreductase (complex III). (2) Transfer of electrons through ADM resulted in the formation of a very strong complex between ADM and CL. This new complex is different and much stronger than the already known ADM-CL complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Doxorubicin / pharmacology*
  • Electron Transport / drug effects
  • In Vitro Techniques
  • Intracellular Membranes / drug effects*
  • Intracellular Membranes / metabolism
  • Membrane Fluidity / drug effects*
  • Mitochondria, Heart / drug effects*
  • Mitochondria, Heart / metabolism
  • Spectrophotometry

Substances

  • Doxorubicin