Pentasomy 21 characterizing spontaneously regressing congenital acute leukemia

Cancer Genet Cytogenet. 1983 May;9(1):19-23. doi: 10.1016/0165-4608(83)90020-1.


Pentasomy 21 was found to characterize the proliferating cells in a case of transient congenital acute leukemia (or congenital acute leukemia) with spontaneous remission. The patient was phenotypically normal, and cytogenetically no evidence could be found for the existence of a mosaic with a normal cell line and one with more than two No 21 chromosomes. The importance of these findings is discussed.

MeSH terms

  • Acute Disease
  • Chromosomes, Human, 21-22 and Y*
  • Humans
  • Infant, Newborn
  • Leukemia / congenital*
  • Leukemia / genetics
  • Leukemoid Reaction / genetics
  • Male
  • Neoplasm Regression, Spontaneous*
  • Polyploidy*