Effect of ovarian hormones on the induction of 1-methyl-1-nitrosourea-induced mammary cancer

Carcinogenesis. 1983;4(4):495-7. doi: 10.1093/carcin/4.4.495.

Abstract

The concomitant administration of 20 micrograms 17 beta-estradiol and 4 mg progesterone/injection (5 days/week) over a 40-day treatment period beginning 10 days after methylnitrosourea (MNU) treatment was as effective as ovariectomy in inhibiting mammary cancers (an 84% reduction from non-hormone treated rats). The primary action of the hormones must have been directed at preneoplastic cells since the hormones were not given until 10 days after MNU (a direct-acting carcinogen with a short half-life).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Drug Interactions
  • Estradiol / pharmacology*
  • Female
  • Mammary Neoplasms, Experimental / chemically induced*
  • Mammary Neoplasms, Experimental / prevention & control
  • Methylnitrosourea / toxicity*
  • Nitrosourea Compounds / toxicity*
  • Progesterone / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Nitrosourea Compounds
  • Progesterone
  • Estradiol
  • Methylnitrosourea