Ileal enteroglucagon cells after ileal-duodenal transposition in the rat

Digestion. 1983;26(1):10-6. doi: 10.1159/000198863.

Abstract

The changes occurring in the ileal wall and in enteroglucagon cells were studied in a rat model of intestinal adaptation, obtained by the transposition of a segment of distal ileum into the mid-duodenum (6 rats, compared with 6 transected controls). After 40 days, the transposed ileal segment, compared to the equivalent segment in the controls, showed striking increase in weight, especially of the epithelium (1,585 +/- 127 vs. 305 +/- 42 mg, mean +/- SEM, p less than 0.0005). The calculated weight of enteroglucagon cells in the segment showed a smaller, but significant increase (1.7 +/- 0.3 vs. 0.8 +/- 0.2 micrograms, p less than 0.05). Plasma enteroglucagon was markedly raised (239 +/- 28 vs. 61 +/- 7.1 pmol/l, p less than 0.0005) and showed a greatly increased meal-stimulated response (1,521 +/- 284 vs. 83 +/- 43 pmol, p less than 0.0005), thus suggesting hyperactivity of enteroglucagon cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Duodenum / surgery
  • Gastrointestinal Hormones / analysis*
  • Glucagon-Like Peptides / analysis*
  • Glucagon-Like Peptides / blood
  • Ileum / analysis
  • Ileum / pathology*
  • Ileum / transplantation
  • Male
  • Rats
  • Rats, Inbred Strains

Substances

  • Gastrointestinal Hormones
  • Glucagon-Like Peptides