Vitamin K content of liver and feces from vitamin K-deficient and butylated hydroxytoluene (BHT)-treated male rats

Toxicol Appl Pharmacol. 1983 Jan;67(1):152-5. doi: 10.1016/0041-008x(83)90253-3.


Vitamin K content of liver and feces from male rats fed diets containing butylated hydroxytoluene (BHT) was estimated by a chick bioassay method to investigate the mechanism of BHT-induced decreases in the activities of vitamin K-dependent clotting factors. The concentration of vitamin K in the liver of rats receiving BHT was reduced as compared to that of control rats. Conversely, the concentration of vitamin K in the feces from rats receiving BHT increased more than that from control rats. The vitamin K deficiency induced by BHT might be due to effects of BHT on absorption and excretion of vitamin K.

MeSH terms

  • Animals
  • Bacteria / metabolism
  • Butylated Hydroxytoluene / toxicity*
  • Feces / analysis*
  • Intestinal Mucosa / metabolism
  • Liver / analysis*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Vitamin K / analysis*
  • Vitamin K / metabolism
  • Vitamin K Deficiency / metabolism*


  • Vitamin K
  • Butylated Hydroxytoluene