Platelet-derived growth factor stimulates bone resorption by monocyte monolayers

Endocrinology. 1983 Feb;112(2):761-2. doi: 10.1210/endo-112-2-761.

Abstract

Resorption of devitalized bone particles by monocytes grown in culture was stimulated by platelet-derived growth factor (PDGF) in a dose-dependent manner. Bone resorption in response to PDGF was time-dependent with a significant increase over control cultures evident by 72 hours. These data are the first to demonstrate stimulation of bone resorption by PDGF in a specific cell type known to resorb bone in vivo and in vitro.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bone Resorption / drug effects*
  • Dose-Response Relationship, Drug
  • Growth Substances / pharmacology*
  • Humans
  • Monocytes / drug effects
  • Monocytes / metabolism*
  • Peptides / pharmacology*
  • Platelet-Derived Growth Factor
  • Time Factors

Substances

  • Growth Substances
  • Peptides
  • Platelet-Derived Growth Factor