Extreme Central Acidosis From Abbott Epinephrine

Am J Med. 1983 Jan;74(1):30-2. doi: 10.1016/0002-9343(83)91114-2.

Abstract

Investigation into the cause of extreme systemic acidosis during cardiac arrest led to the discovery that a major contributing factor was Abbott 1:10,000 single-dose epinephrine, which contained a large unsuspected acid level. Analysis of this product, both in vivo and in vitro, demonstrated that it contained 8.2 times the acid content of a presumably identical product from Bristol Laboratories and also of a presumably identical product from Bristol Laboratories and also 1,850 times the acid content of an identical epinephrine dose made from a Parke-Davis preparation. Abbott epinephrine injected into the central circulation or directly into the heart causes extreme acidemia, which may be potentially lethal by itself when superimposed on pre-existing acidosis as in cardiac arrest.

Publication types

  • Comparative Study

MeSH terms

  • Acidosis / chemically induced*
  • Epinephrine / administration & dosage
  • Epinephrine / adverse effects*
  • Epinephrine / analysis
  • Heart Arrest / blood
  • Heart Arrest / drug therapy
  • Humans
  • Hydrogen-Ion Concentration

Substances

  • Epinephrine