[Possible mechanism of membrane fusion]

Biofizika. Mar-Apr 1983;28(2):242-7.
[Article in Russian]

Abstract

The stalker mechanism of membrane fusion was considered. Initiation and evolution of monolayer and bilayer bridges-stalks between the membranes were studied. From the expression of elastic energy of the stalk the value of spontaneous curvature of its membrane Ks at which the bridge may appear, was found. It was shown that in terms of the stalker mechanism formation of the stalk of the final radius or complete fusion were possible Ks values for realizing this or that variant were found. The energetic barrier of hydrophobic interaction and the barrier of elastic energy which the membranes had to overcome for stalker formation were found. The experimental data on the fusion of small and large liposomes were analysed.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cell Fusion*
  • Liposomes*
  • Mathematics
  • Models, Structural*

Substances

  • Liposomes